Various experiments of a biological, chemical or physical nature are carried out at an almost daily basis on the ISS space laboratory. Reliabilty of instrumentation is the most important factor. Therefore some of the experiments were tested on Earth under weightlessness simulated. This is why those instruments are temporary brought into the orbit with small rockets. In this context, for the measurement of various electrical and physical parametres, highly precise and reliable sensors are essential. Therefore the DDM pressure sensor PV 15 series was selected and proven to perform as expected.